plasmodium knowlesi การใช้

• His best known publication is probably the description of " Plasmodium knowlesi " in 1927.
• "Plasmodium knowlesi " has been known since the 1930s in Asian macaque monkeys and as experimentally capable of infecting humans.
• "Plasmodium knowlesi " is the sixth major human malaria parasite ( following the division of " Plasmodium ovale " into 2 subspecies ).
• Malarial parasites were seen on the blood film and later identified as " Plasmodium knowlesi " by PCR . At post mortem the liver and spleen were enlarged.
• The " Plasmodium " species was not given a name by Knowles and Das Gupta but was named " Plasmodium knowlesi " by Sinton and Mulligan in 1932.
• This parasite is transmitted by the bite of an " Anopheles " mosquito . " Plasmodium knowlesi " has health, social and economic consequences for the regions affected by it.
• The 66kDa merozoite surface antigen ( PK66 ) of " Plasmodium knowlesi ", a simian malaria, possesses vaccine-related properties believed to originate from a receptor-like role in parasite invasion of erythrocytes.
• The sample was first thought to be " Plasmodium knowlesi " due to the morphological similarities of the two species, but was later identified as separate due to having a tertiary periodicity compared to " P . knowlesi "  s quartan periodicity.
• This was followed by the recognition of the other two species of " Plasmodium " which infect humans : " Plasmodium ovale " ( 1922 ) and " Plasmodium knowlesi " ( identified in long-tailed macaques in 1931; in humans in 1965 ).
• The morphology of " Plasmodium knowlesi " is similar to that of " Plasmodium malariae " . " P . malariae " is characterized by a compact parasite ( all stages ) and does not alter the host erythrocyte's shape or size or cause enlargement.
• Although the current infection rate with " Plasmodium knowlesi " is relatively low, one risk it presents is misdiagnosis with other forms of malarial parasites such as " P . malariae " especially when microscopy is used . " P . knowlesi " can only be accurately distinguished from " P . malariae " using PCR assay and / or molecular characterization.